Playing in the Predator Campaign, players control a clan that must win the respect of the Ancients, introduced as the rulers of the Predator race, and in order to win their approval you must hunt a legendary beast called the Gro'Tye, and after that you must hunt the Alien hive in several missions in the campaign.
The game allows the player to control three different species: Aliens, Predators and Colonial Marines-another organization originally featured in the Alien film series and subsequently seen throughout the AvPseries.
In Aliens Versus Predator: Extinction, the Weyland-Yutani Corporation sets up a colony on planet LV-742 after discovering a battle between a clan of Predators and an Alien hive. Meanwhile, the colony of Aliens escape and attempt to overwhelm both factions. Minor battles between the humans and the Predators soon escalate into an all-out war. Humans arrive on a newly colonized world known as LV-742 and discover an Alien (Xenomorph) colony, unaware that a hunting party of Predators are also present on the planet, stalking their favoured species, the Xenomorphs.